Protein Details: Chloride channel protein CLC-e

Protein ID

ICDB_Pro_1242

Protein Name

Chloride channel protein CLC-e

Gene Name

CLC-E; CBSCLC3; At4g35440; F15J1.10; F23E12.10

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

710 amino acids

AlphaFoldDB

AF-Q8GX93-F1-model_v4.pdb

Function

Voltage-gated thylakoid chloride (Cl) channel/transporter involved in chloride homeostasis after transition from light to dark . Influences chloroplast ultrastructure and subsequent photosynthetic electron transport . During photosynthetic response on transition from dark to low light; involved in a sequential mechanism of adaptation; VCCN1 and CLCe first trigger the activation of photoprotection; which is later down-regulated by KEA3 to a low steady state; while adjusting electron transport . Regulates photosynthesis by a pH-independent mechanism likely involving Cl(-) homeostasis .

Sequence

MAATLPLCAALRSPVSSRRFAPIHKTDVPFQFNVVLSPFFGSVAIGGRIFPRLPAAKQETDQDEVGFDQQPSQELAIASACLVGVLTGVSVVLFNNCVHLLRDFSWDGIPDRGASWLREAPIGSNWLRVILVPTIGGLVVSILNQLRESAGKSTGDSHSSLDRVKAVLRPFLKTVAACVTLGTGNSLGPEGPSVEIGASIAKGVNSLFNKSPQTGFSLLAAGSAAGISSGFNAAVAGCFFAVESVLWPSSSTDSSTSLPNTTSMVILSAVTASVVSEIGLGSEPAFKVPDYDFRSPGELPLYLLLGALCGLVSLALSRCTSSMTSAVDSLNKDAGIPKAVFPVMGGLSVGIIALVYPEVLYWGFQNVDILLEKRPFVKGLSADLLLQLVAVKIAATAWCRASGLVGGYYAPSLFIGGAAGMAYGKFIGLALAQNPDFNLSILEVASPQAYGLVGMAATLAGVCQVPLTAVLLLFELTQDYRIVLPLLGAVGMSSWITSGQSKRQETRETKETRKRKSQEAVQSLTSSDDESSTNNLCEVESSLCLDDSLNQSEELPKSIFVSEAMRTRFATVMMSTSLEEALTRMLIEKQSCALIVDPDNIFLGILTLSDIQEFSKARKEGNNRPKDIFVNDICSRSGGKCKVPWTVTPDMDLLAAQTIMNKHELSHVAVVSGSIDAPRIHPVGVLDRECITLTRRALATRMYLLNSLYL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1038/47134; 10.1111/tpj.13415; 10.1126/science.1071006; 10.1186/1471-2164-10-200; 10.3389/fpls.2016.00115; 10.1038/s41598-019-44972-z

RefSeq

NP_567985.1 [Q8GX93-1]